Saturday, March 30, 2019

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis


Link to Abstract

Full PDF available once you click the link above.

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

Friday, March 29, 2019

The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis



Link to Abstract

Link to PDF

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

Passive leg raising: how to do it



Link to Abstract

Link to PDF

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

Oxygen There may be such a thing as too much oxygen..

The effect of hyperoxia on mortality in critically ill patients: a systematic review and meta analysis

Do your patients have supplemental oxygen and sats of 100% on the monitor? If so, they may be getting too much oxygen. Wean the supplemental oxygen as we have data that this causes harm. I encourage you to read this article which you can download on my website, eddyjoemd.com. I’m making an effort to review articles for you all that you can download for free and not have to pay ridiculous fees to stay up to date. You can like my posts and YouTube videos and donate $10 to your favorite charity instead 😁. Thank you to the authors, as always because I do not do research myself.

-EJ


Link to Abstract

Link to PDF

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

Tuesday, March 26, 2019

Hyperchloremic Metabolic Acidosis and Acute Kidney Injury

Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients

A lot of the research I do on my own time to be a better doctor includes the simple basics of critical care. I don’t delve too much into the esoteric things bc it doesn’t impact as many lives as what I do on a DAILY basis. That’s the reason why I’m obsessed with fluids and sharing what I’ve learned along the way leading to how my practice has changed. Keep in mind that even LR could lead to an increase in the serum Cl (nl 98-109 and LR has 109mmol/L). I have made a video on YouTube describing the different fluids side by side that I made when I was a fellow. Since then, I have made individual videos covering NS, LR, and Plasma-Lyte. I really hope that some of you are benefitting from these posts. I appreciate the feedback I’ve received. Hat tip to the authors.

-EJ 



Link to Abstract

Link to PDF

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

Marik Protocol for Septic Shock: Looking at Vitamin C

Hydrocortisone, Ascorbic Acid and Thiamine
(HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid

Controversies. Controversies. Controversies. I tell you, the behaviors of Intensivists when it comes to king septic patients IV Vitamin C for sepsis are quite perplexing. We had a cheap drug, less than;$20 a day that MAY help treat sepsis and people don’t even bother to try it out. I know I use it because if it saves lives, why not try? Let’s say that the trials show a mortality benefit, two years have already passed since the first trial. Think of all the additional lives you could have saved but didn’t because your ego was in the damned way. If Marik is wrong, nothing bad happened. But if he’s right, you’re going to beat yourself up.

-EJ 



Link to Abstract

Link to PDF

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

Articles that I have used for my Instagram Posts as of 3/25



https://jamanetwork.com/journals/jama/article-abstract/2725234



https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-019-0506-y
https://annalsofintensivecare.springeropen.com/track/pdf/10.1186/s13613-019-0506-y



https://www.nejm.org/doi/full/10.1056/NEJMoa1812405?query=pulmonary



https://onlinelibrary.wiley.com/doi/full/10.1111/anae.14472



https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2368-y
https://ccforum.biomedcentral.com/track/pdf/10.1186/s13054-019-2368-y



https://link.springer.com/epdf/10.1007/s00134-019-05561-w?shared_access_token=rTeiylWJdlL3VwqGpj4Kq_e4RwlQNchNByi7wbcMAY643av82qwwcII63__HlENh6YhUR4ZGkthQ4JdHcBeAV8Z7KNOkmV_O79HdliiumiAUAvOLvY0NPXmgLces5SGUvXWZvUJa9gprHlZMUdPakg%3D%3D



https://link.springer.com/epdf/10.1007/s00134-019-05526-z?shared_access_token=6MIrpEk5bbwEEnz4YIjB7ve4RwlQNchNByi7wbcMAY6T8cDofZacKXv6q8aKiyjTVK8EN5sZ_Tbg_x-Wvs85hhWRP7ub2_lfLCAkg3hlEwEfk7wrEmLYnR0czZRpccOV3RsbGzeUxyHPFoSFFD9YnHKEjA973oyayPosMnfs--g%3D

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

Friday, October 13, 2017

Journal Club-ish 4.1

Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association
http://circ.ahajournals.org/content/early/2017/09/18/CIR.0000000000000525

This an open access from the AHA regarding management of Cardiogenic Shock. This is good stuff. There's nothing brand new (to me at least) but it's always good have the (mostly) updated data in one place. Of course, I'm solely going to touch on the topics of Medical Management because I can't perform PCI nor introduce Impellas (yet). 

Here are a couple of key points that I like: 
  • "Although the CICU environment may be best suited to centralize cardiac care of patients with CS, attending cardiologists and teams may not have the dedicated training to address the ancillary multi-system organ failure often associated with CS." There are little smiling emojis with the hearts for eyes all over this point. I don't want to incite a specialty war here, but I prefer to be involved in the care of these patients. That's my specialty-induced bias. 
  • They don't recommend a set MAP target. This makes a lot of sense to me since everyone is different and BP does not equal a good cardiac output. Lots of training in the CVICU world proved this to me (thanks fellowship!). What they recommend is to look at the patient, check lactates, mixed venous blood gases, UOP, LFTs, renal function, temperature, and, of course, look at your patient! I purposefully repeated the last part to emphasize it.
  • This next point is a mixed bag. First of all, they call out dopamine for what it is; "Dopamine was associated with a higher rate of arrhythmias in the CS and overall populations and was associated with higher risk of mortality in the CS subgroup". But then they go ahead and list it as first line using either it or Norepinephrine in table 5 for initial vasoactive management considerations (which is a great table, by the way). They also show a dose-related receptor binding model which I could've sworn was disproven. I need to find that data now for you all. 
  • Thank you for not touching on the mode of mechanical ventilation in these patients. Also, good job in addressing the "potential deleterious effect of hyperoxia in patients with ACS, HF, and OHCA and in general ICU patients". That's something we see too often that we need to improve upon. 
  • Did I already mention that I liked table 5? Well, I like table 5. 
A couple points I don't like: 
  • They recommend checking CVPs. Ugh. I guess if you trend the number instead of of just taking the textbook numbers as being normal then you may be okay. Ultimately, I recommend that you become comfortable with bedside echo, the intensivists new best friend. At the time of this writing, the ever elusive method to volume status continues to be ever elusive. 
  • They don't really dig in to the argument of using CRRT/ultrafiltration to offload the heart which I believe is reasonable. I'm not going to go into the studies of early vs. late dialysis nor the studies of using ultrafiltration to offload the heart. That's a topic for another day. I guess the AHA felt the same way. 
  • The whole dopamine thing I ranted about above. Yeah, I don't like that. 
At the end of it all, just read the article for yourself. It's worth your time instead of scrolling through Instagram a few times. Thanks to the authors. These things must be a beast to put together.

I was going to write JC-ish 5.0 but this article got me all excited and took up far more time than intended as I was dissecting it. I'll just call it 4.1.   

-EJ

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

Tuesday, October 10, 2017

Journal Club-ish 4.0

2017 EACTS Guidelines on perioperative medication in adult cardiac surgery
A 29 page PDF which is pretty extensive in its coverage of the perioperative management regarding medications in the CTS patients. It's free and a must-read for everyone taking care of this patient population

Antibiotic therapy, supportive treatment and management of immunomodulation-inflammation response in community acquired pneumonia: review of recommendations
This is also an open access article.  Some of the goodies of the include: 
"There are no specific recommendations regarding the proper duration of antibiotic treatment"
- So the 8 days vs. 14 days assumptions go out the door. 
"the duration of antibiotic treatment can be guided by the trend of procalcitonin levels; antibiotic could be interrupted when PCT levels reach 0.1 ng/ml"
- We should be checking PCT, acknowledging the limitations of this, during the course of the ICU stay.
"patients with more severe respiratory failure (PaO2/FiO2 < 200) had lower risk of intubation if treated with HFNC compared to traditional oxygen or NIV, indicating a possible role of this technique in this type of patients"
- There are other studies that show HFNC to be superior to NIV(BiPAP) in PNA. 
We also don't need to give vancomycin and zosyn to everyone who comes to our ICU's with PNA

Acute-on-chronic liver failure: recent update 
This is more of a pathophysiology article rather and a how to manage article. I am not going to lie, I just skimmed through this article as it was a bit too dense for what I can process right now. I'll get back to this one at some point soon. 

Update in Management of Severe Hypoxemic Respiratory Failure
This one is a contemporary review from Chest; the need to know articles. 
Key points:
- if the P/F ratio <150, think about paralyzing and proning 
- tidal volume of 4-8 cc/kg of IBW, decrease to 4 if plateau presses > 30 (if chest wall is normal)
- there's some cool info regarding high PEEP vs. low PEER and mortality
- they explain some recruitment maneuvers 
- table 3 has some key potential benefits of prone positioning
- there's a nice management flow chart towards the end.
- needless to say, I printed a bunch of these out and handed them to my staff. 

Efficacy and safety of a balanced salt solution versus a 0.9% saline infusion for the prevention of contrast-induced acute kidney injury (BASIC trial): a study protocol for a randomized controlled trial
A heads up on a study being performed in South Korea which is basically NS vs. what we call plasma-lyte here in the States. He's the kicker, it's being sponsored by the pharmaceutical company producing the balanced salt solution. 

Once again, thanks to Rob Mac Sweeney at criticalcarereviews.com. You should definitely subscribe to his email list and check out his work.

-EJ

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.

Brachial Arterial Catheterization

Since I've started working at my new institution, I've placed two brachial arterial lines and an axillary line. As any intensivist will admit, if you're looking elsewhere from the radial, it means that the patient is pretty sick and you need some results, quickly.

While performing this procedure, I've received strange looks from the nurses as they are unfamiliar with the location. Where I trained, I saw anesthesia commonly place these without any issues in the cardiac surgery population. I decided to do a bit of a search for the data behind the safety of this procedure.

First of all, why should we worry? The brachial artery lacks collateral circulation. As with any other line, we worry about clinical ischemia, nerve injury (which is the median nerve in the case of the brachial artery), and infection. What's the data behind these, though?

Here are some of the more recent studies. I'll let you all decide for yourselves after you read the articles. Thanks to the authors!

Clinical review: Complications and risk factors of peripheral arterial catheters used for haemodynamic monitoring in anaesthesia and intensive care medicine
Published in 2002 in Critical Care. This is an open access article. 
"Only one serious complication was found in a study of 1000 patients in which the brachial artery was used for invasive monitoring in ambulatory patients. This complication was an infected haematoma arising from a pseudoaneurysm. Another study that employed the brachial artery for arterial blood sampling in 6185 patients also showed a small number of complications (incidence 0.2%), mainly paresthesias." 

Brachial Arterial Pressure Monitoring during Cardiac Surgery Rarely Causes Complications
I cannot obtain full access to this study published in June of 2017 but it can be found here: 
Review of their abstract shows that their study population was exclusively in cardiac surgery patients and they looked at vascular issues, nerve injury, and infections as complications
They concluded that "Among 21,597 qualifying patients, 777 had vascular or nerve injuries or local infections, but only 41 (incidence 0.19% [95% CI, 0.14 to 0.26%]) were potentially consequent to brachial arterial cannulation. Vascular complications occurred in 33 patients (0.15% [0.10 to 0.23%]). Definitely or possibly related infection occurred in 8 (0.04% [0.02 to 0.08%]) patients. There were no plausibly related neurologic complications."

Brachial Artery Catheterization: An Assessment of Use Patterns and Associated Complications

Published in 2012 in Anesthesia and Analgesia. This is open access so you can obtain a copy for yourself! 
This was a retrospective study with 858 patients. "the overall rate of vascular and neurologic complications was low in both brachial and radial artery catheterization groups (3 [0.35%] vs 1 [0.03%], brachial versus radial, respectively; P = 0.03). No cases of catheter-related bloodstream infection were identified in either cohort."

There are some older studies which I need to briefly glance at but I wanted to get this out there and I'll add some more goodies later. 

-EJ

Although great care has been taken to ensure that the information in this post is accurate, eddyjoemd, LLC shall not be held responsible or in any way liable for the continued accuracy of the information, or for any errors, omissions or inaccuracies, or for any consequences arising therefrom.